Directed Molecular Evolution – Applications in Biocatalysis

drug discovery are announced on a regular basis, it is rare for an entirely new technology to emerge within the pharmaceutical bulk active and synthesis sector. Such a technology – developed by Codexis, Inc – enables the rapid discovery and development of novel or improved processes for the cost-effective synthesis of chemicals, using breakthrough biocatalysts and fermentation strains. Furthermore, by allowing processes to take place under less severe conditions (ambient temperature, atmospheric pressure, avoidance of hazardous reagents), the technology is helping to make ‘green chemistry’ a reality.